ORIGINAL ARTICLE
Year : 2018 | Volume
: 20 | Issue : 1 | Page : 49--56
Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis
Ochaka J Egesie1, Patricia A Agaba2, Olugbenga A Silas3, Chad Achenbach4, Ayuba Zoakah5, Oche Agbaji6, Jeremiah A Madaki2, Edith N Okeke6, Lifang Hou7, Atiene A Sagay8, Robert Murphy4
1 Department of Hematology and Blood Transfusion, University of Jos/Jos University Teaching Hospital, Jos, Nigeria
2 Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria
3 Department of Histopathology, Jos University Teaching Hospital, Jos, Nigeria
4 Department of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
5 Department of Community Medicine, Jos University Teaching Hospital, Jos, Nigeria
6 Department of Internal Medicine, Jos University Teaching Hospital, Jos, Nigeria
7 Department of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL; Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
8 Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
Correspondence Address:
Dr. Patricia A Agaba
Department of Family Medicine, University of Jos/Jos University Teaching Hospital, P.M.B 2076, Jos, Plateau State
Nigeria
Background: Hematologic malignancies cause significant morbidity and mortality and are not uncommon in resource-limited low-income countries. However, the types, pattern of presentation, and treatment outcomes vary across regions. We assessed the presentation and overall survival (OS) over an 11-year period in adult patients with hematologic cancers in Jos, North Central Nigeria.
Materials: and Methods This retrospective outcome study evaluated patients who presented with hematologic malignancies between 2005 and 2015 at the Jos University Teaching Hospital, Jos. Variables of interest were abstracted through chart reviews. Descriptive statistics were used to evaluate baseline and follow-up parameters. OS was assessed by using Kaplan–Meier method.
Results: Sixty patients, contributing 25,994 person-days of follow-up were evaluated. The mean age was 43 ± 17 years and 61.7% were males. Thirty-one patients (51.7%) presented with leukemia, 45.0% with lymphoma, and 3.3% with multiple myeloma. Forty-two (70.0%) presented with advanced disease, 5 (5.2%) were human immunodeficiency virus positive and 4 (6.7%) had died at the end of follow-up. OS was 84.3% (95% confidence interval: 58.1–94.7). Survival differed by disease group (P = 0.01) and having fever at presentation (P = 0.02).
Conclusion: We found long-term OS to be impacted by disease type and status of fever at presentation. Disease-specific strategies to improve early diagnosis and therapies are needed to ensure optimal outcomes in Nigerian patients.
How to cite this article:
Egesie OJ, Agaba PA, Silas OA, Achenbach C, Zoakah A, Agbaji O, Madaki JA, Okeke EN, Hou L, Sagay AA, Murphy R. Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis.J Med Trop 2018;20:49-56
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How to cite this URL:
Egesie OJ, Agaba PA, Silas OA, Achenbach C, Zoakah A, Agbaji O, Madaki JA, Okeke EN, Hou L, Sagay AA, Murphy R. Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis. J Med Trop [serial online] 2018 [cited 2023 Oct 2 ];20:49-56
Available from: https://www.jmedtropics.org/article.asp?issn=2276-7096;year=2018;volume=20;issue=1;spage=49;epage=56;aulast=Egesie;type=0 |
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